Metformin is the first drug of choice prescribed for type 2 diabetes, by all standards. It is time-tested, proven, has good efficacy, a good safety profile and it’s cheap. Metformin pills aren’t perfect, but they can help to lower sugar levels for many people with type 2 diabetes, and it’s sometimes prescribed for prediabetes as well.
In fact, based on the American Diabetes Association 2019 Standards of Medical Care in Diabetes, “Metformin, if not contraindicated and if tolerated, is the preferred initial pharmacologic agent for the treatment of type 2 diabetes.”
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Buy Metformin online without prescription
Metformin (Brand name: Glucophage) is a generic medication prescribed for the treatment of type 2 diabetes.
Available Options: 500 mg, 850 mg, 1000 mg
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What is Metformin?
Metformin is the most common blood sugar-lowering medication for diabetes, and with a proper diet and exercise program helps bring blood sugar under control. Type 2 diabetes is the condition in which the body does not make enough insulin that affects about 30 million Americans. This can cause high blood sugar levels (hyperglycaemia). High blood sugar coursing through your body destroys your eyes, kidneys, heart, brain, and more.
Metformin belongs to a group of medicines called biguanides. Biguanides are derivatives of guanidine, guanidine is found in an herb called goat’s rue (also known as French lilac), and this herb has been used to treat diabetes since the early 1900s. It lowers high blood glucose levels by:
The drug is available as a single-ingredient and in combination products for the treatment diabetes.
For over than 60 years, Metformin has been one of the most effective, well tolerated, antidiabetic treatments prescribed worldwide (it’s been prescribed to more than 150 million people worldwide). Why? Metformin is safe, effective, and inexpensive. It’s unique because unlike most other drugs it lowers blood sugar without increasing insulin secretion. Metformin is now widely available as a relatively inexpensive generic medication. These cost less than brand-name products and in general are reliable.
Metformin (which is also sold under the trade names Glucophage) contains the active ingredient metformin hydrochloride. You can buy Metformin online from registered pharmacy. The cost for metformin oral tablet 500 mg is around $35 for a supply of 90 tablets, depending on the pharmacy you visit. We offer a convenient and safe online pharmacy service for people with a busy schedule to save them time, hassle and money.
The most common Metformin brand name is Glucophage, but there are many other less common Metformin brands.
Other Brand Names for Metformin include:
Diabex®, Diaformin®, Formet®, Riomet®, Fortamet®, Metforbell®, Glucophage®, Glucohexal®, Glucomet®, Gluformin®, Siofor®.
What is Metformin XR?
XR stands for extended release. The metformin XR formulation releases the active drug through hydrated polymers which expand after uptake of fluid, prolonging gastric residence time which leads to slower drug absorption.
Slow-release tablets dissolve slowly so you do not have to take them as often. Metformin extended release versions may be prescribed for people experiencing significant gastrointestinal intolerance as a result of standard metformin. One dose is usually enough, and you’ll take it with your evening meal. Metformin XR is currently available in multiple branded and generic formulations.
Brand Names for Metformin XR:
Glucophage XR®, Diabex®, Diaformin XR®, Metex XR®.
What is metformin used for?
Metformin is often prescribed as the first diabetes tablet for people with type 2 diabetes who are overweight. It generally doesn’t lead to weight gain and may help to manage weight. An ideal anti-diabetic drug would enhance cellular insulin sensitivity, inhibit excess intestinal absorption of sugar, reduce excess liver production of glucose, promote weight loss and reduce cardiovascular risk factors. Metformin (Glucophage) is the one drug that does all of this and more.
It is also being investigated for potential cancer-fighting and cardioprotective benefits.
Metformin isn’t a weight loss drug, but researchers have found a link between the drug and weight loss. Study published in the journal Diabetes Care (April 2012) that was conducted by the Diabetes Prevention Program (DPP) concluded that the drug could serve as a treatment for excess body weight.
Metformin is also used to treat polycystic ovarian syndrome (PCOS). Metformin may help start ovulation in women with PCOS who have not responded to treatment with clomiphene. Some doctors may recommend taking metformin in addition to clomiphene to start ovulation.
Researchers are now also investigating whether metformin might improve symptoms of autoimmune disorders, tuberculosis, and erectile dysfunction, among other conditions.
How does Metformin work?
For most people with type 2 diabetes, metformin works to bring down blood sugar gradually when combined with a healthy diet and exercise. When you’re diabetic you lose the ability to use the insulin you need to offset the food. Diabetes medicine Metformin and drugs in that category will help your body better metabolize that food so that insulin levels will be able to stay more in line.
Metformin 500 mg tablet works by reducing the amount of glucose made by the liver and by making it easier for glucose to enter into the tissues of the body. Physiologically, metformin acts directly or indirectly on the liver to lower glucose production and makes muscle cells more sensitive to insulin. At the molecular level, metformin inhibits the mitochondrial respiratory chain in the liver, leading to enhancing insulin sensitivity and lowering cAMP, thus reducing the expression of gluconeogenic enzymes.
Metformin 500: Each film coated tablet contains Metformin HCL 500 mg
Metformin 850: Each film coated tablet contains Metformin HCL 850 mg
List of excipients
Please Note: Different generic brands of Metformin may contain different inactive ingredients.
In addition to the active ingredient metformin hydrochloride, each tablet contains the following inactive ingredients: cellulose acetate, hypromellose, magnesium stearate, macrogol 6000, polyethylene glycols, povidone, purified talc, synthetic black iron oxides and titanium dioxide.
Metformin 500 mg, 850 mg and 1000 mg tablets are Lactose and Gluten free.
Metformin IR (immediate release) is available in 500, 850, and 1000-mg tablets. The dosage is based on your medical condition, response to treatment, and other medications you may be taking.
For treating type 2 diabetes in adults, metformin usually is begun at a dose of 500 mg twice a day or 850 mg once daily, if necessary, increased over a few weeks up to a maximum of 1000 mg three times per day. If extended tablets are used, the starting dose is 500 mg or 1000 mg daily with the evening meal.
Average dose of Metformin: Metformin is taken at doses of 500 to 2550 milligrams a day, typically starting with a lower dose of 500 mg.
Maximum dose of Metformin: The maximum dose of metformin is 2,550 mg per day.
Metformin For PCOS: Doctors usually start off with metformin for PCOS with a single dose of 500 mg with your largest meal. This is to avoid digestive issues.
Metformin dosage for weight loss: You need to be taking somewhere between 1,000 mg to and 2,000 mg per day in order to get optimal results. You’ll likely start metformin at a low dosage and gradually increase it over a few weeks.
How to take Metformin
Always take metformin with food – during a meal or just after a snack. The extended-release formula (Metformin XR) is taken once a day, with the evening meal. Swallow the tablet or extended-release tablet whole with a full glass of water. Do not crush, break, or chew it. Drink a full glass of water each time you take metformin. It will also make you feel full and reduce your cravings to eat.
The dose must be increased slowly, one tablet of 500 mg 3 times daily or one tablet of 850 mg 2 times daily is often enough to control diabetes. This can be accomplished in a few days, but this effect is not uncommon to new achievements within two weeks.
If required the tablet 850 mg can be administered 3 times a day. When the symptoms of diabetes has been controlled, there is the possibility of a dose can be lowered.
Take this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day.
What do I do if I miss a dose?
Skip the missed dose and go back to your normal time unless your doctor tells you to do something else.
Metformin costs in the United States are comparably expensive to other countries. Some Americans drive to Canada for their medications. But for those who aren’t near a bordering nation, the idea of buying Metformin online becomes increasingly attractive. On our website, it is easy to find current information about Metformin prices in online pharmacies.
Metformin 500 mg
$0.26 – $0.37 per pill
Product Code: Metformin 500 mg
Availability: In Stock
This drug may be available via mail order. SafeRX.com is the first choice when looking to for safe drugs.
Metformin 850 mg
$0.54 – $0.75 PER PILL
Product Code: Metformin 850 mg
Availability: In Stock
This drug may be available via mail order. SafeRX.com is the first choice when looking to for safe drugs.
Always ask for the least costly version of metformin, as some generics may be more expensive.
How effective is Metformin?
Metformin an old but still the best treatment for type 2 diabetes. Metformin in the USA was the eighth most commonly prescribed drug consistently from 2008 to 2012, according to the IQVIA Institute for Human Data Science.
If you are a person with type 2 diabetes, there are plenty of benefits to taking metformin for its original, intended purpose. Metformin is a quick-acting oral medication — you will typically see some effect within 48 hours of starting the medication. Maximum effect will take about four to five days, but that depends on the dose. How long this takes will depend on what your health care provider prescribes and how you respond to the medication.
Metformin not only lowers blood glucose levels, which in the long term reduces the risk of diabetic complications, but it also lowers blood cholesterol and triglyceride levels.
It’s a very powerful antioxidant. It helps to keep cells safe, by reducing the by-products that occur when cells burn glucose for energy.
Metformin, like any medicine, results in a spectrum of response. A quarter of the patient population does extremely well. Half the population does rather well, and a quarter of the patient population doesn’t do well at all.
Metformin for PCOS
Polycystic ovary syndrome (PCOS) is a health problem that affects 1 in 10 women of childbearing age. PCOS is a condition characterised by chronic failure or absence of ovulation (anovulation) and excessive production of male hormones (hyperandrogenism). The majority of women with PCOS have high insulin levels which cause weight gain. Metformin works to lower your insulin and reduce your risk for diabetes.
Now in both the United States and the United Kingdom, women diagnosed with PCOS who are insulin resistant are advised to take metformin to encourage fertility. Women who take Metformin for PCOS may see improvements in some of their symptoms, such as hirsutism, irregular menstrual cycles, and weight gain.
There are many experimental and clinical studies which have shown an array of potential benefits of metformin other than in the treatment of diabetes.
Downsides of metformin include reduced efficacy with advancing age and reduced efficacy with prolonged use.
Though Metformin is really a well recognized useful drug in the treatment of diabetes, it comes along with few negative effects that do not cause significant hazards to wellbeing if properly handled. About a third of people who take Metformin have stomach upset such as nausea, diarrhea, gas, and loss of appetite, which usually go away over time.
The common gastrointestinal side effects can be minimised by titrating the dose up slowly, taking the medication with/after food and, if necessary, switching to the extended-release preparation.
The following side effects have been reported by at least 1% of people taking this medication:
Atherosclerosis which is the result of plaquing in the blood vessels, is another known side effect of Metformin.
Lactic acidosis is very rare (9 per 100,000) , but potentially severe, consequence of therapy with metformin; it is characterized by elevated blood lactate levels (>5 mmol/L).
Who should NOT take this medication?
Metformin is not recommended for use in the following cases:
Use with caution in patients with congestive heart failure, fever, trauma, surgery, the elderly, renal impairment, or hepatic impairment.
If you drink alcohol frequently or tend to drink a lot at one time, be sure to share this information with your doctor before starting metformin.
Cautions with other medicines
Clinically significant drug interactions involving metformin are rare. Remind your doctor and/or pharmacist that you are taking Metfromin when any new drug is prescribed or a change is made in how you take a drug already prescribed.
Concomitant administration of cimetidine, furosemide, or nifedipine may also increase the concentration of metformin.
Over time, blood levels of vitamin B12 can decrease in some people who take metformin hydrochloride 500 mg. Your body needs this B vitamin to make blood cells and to keep your nervous system healthy. Monitor B12 serum concentrations periodically with long-term therapy.
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Can I ever stop taking metformin?
Diabetes management is about more than medicines, though. Lifestyle factors and exercise play their role, too. Reducing the dosage of metformin or stopping it altogether is safe in some cases if your diabetes is under control. You may be able to stop taking it if your doctor thinks you can maintain your blood sugar without it.
How much does Metformin 500 mg cost without insurance?
It is available in brand and generic versions. The lowest price for the metformin Generic is around $34 for a supply of 90 tablets.
How to buy Metformin online without a prescription?
Generic metformin and Glucophage are prescription medications. Although, some pharmacies allow you to buy Metformin online without a prescription. When buying prescription drugs online, one must be careful to assure that the online pharmacy is reputable. The best way to avoid purchasing counterfeit medicine is to be well informed and selective about where you purchase your medications.
How safe is Metformin?
Overall it has a very good safety record. You can find 18,000 scientific papers referencing Metformin and a number of human clinical trials. In general, diabetes pills are safe and work well. But like any other drug, they must be used with care. Metformin is safe for long term use provided it is taken correctly and you follow the directions given by your doctor.
Can Metformin cause hair loss?
Taking metformin long-term may increase the risk of vitamin B-12 deficiency, which can sometimes cause hair loss. However, it is also possible that hair loss in people taking metformin is a result of a health condition rather than the medication.
Can you drink alcohol with Metformin?
Alcohol doesn’t actually affect the metformin itself, but it can have a direct effect on your diabetes. Drinking alcohol while taking metformin can increase the risk of getting low blood sugar (hypoglycaemia) and lactic acidosis.
Metformin is the Glucophage generic?
You may be wondering what the Glucophage generic is. It is Metformin. Generic medications have exactly the same active ingredients as their branded counterpart.
Date of latest renewal: 01 March 2020